A well-chosen captive-bred panther chameleon that is cared for properly should not normally experience many health problems during the course of its life. That said, there might be times when a captive chameleon does display signs of ill health, and it is extremely important to be able to recognize the signs of illness.
Panther chameleons are susceptible to a multitude of health problems including those resulting from pathogens, infections, parasites, as well as those relating to improper care such as dehydration, thermal burns, vitamin and mineral deficiencies, and the dreaded metabolic bone disease (MBD). For this reason it is vitally important to observe individuals daily and seek advice should anything out of the ordinary be detected.
Panther chameleons tend not to show signs of illness until conditions have become serious, so it is incredibly important to act quickly. Locating a reputable veterinarian in your local area is critically important. Ideally the chosen veterinarian will be a specialist in reptiles with an excellent working knowledge of chameleon biology and healthcare. The Association of Reptilian and Amphibian Veterinarians are always happy to help locate such specialists in your area and should be consulted if finding a suitable veterinarian proves problematic.
Another excellent source of help is the Chameleon Forums Health Section. This section of the Chameleon Forums website is an excellent resource that was created to help chameleon owners diagnose a wide range of health problems, but is no substitute for an experienced reptile veterinarian.